Mesenchymal stem cells enhance recovery and repair following ventilator-induced lung injury in the rat.
RatOtherSprague-DawleyMaleIntravenous injection2 x 10^6 cells per doseFirst dose immediately after recovery from injurious ventilation, second dose 2…
Model: Ventilator-induced lung injury produced by injurious mechanical ventilation in anaesthetised rats followed by recovery
Mesenchymal stem cell therapy enhanced repair after ventilator-induced lung injury, restoring oxygenation and compliance, reducing total lung water, inflammation and histological injury, lowering alveolar TNF-alpha and raising interleukin-10. Rat fibroblasts had no such effect. The cell-free secret…
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.