Kollidon VA64, a membrane-resealing agent, reduces histopathology and improves functional outcome after controlled cortical impact in mice.
MouseTBIControlled cortical impactMaleIntravenous (comparator agents also given intracerebroventricularly)1 mmol/L, 500 microlitres1 h after controlled cortical impact
Model: Controlled cortical impact traumatic brain injury
Kollidon VA64 resealed injured cell membranes in vivo and significantly reduced acute cellular degeneration, chronic tissue damage, oedema, blood-brain barrier damage and motor deficits, although it did not rescue pulse-labelled propidium iodide positive cells from eventual death.
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