Accelerated skeletal muscle recovery after in vivo polyphenol administration.
RatCrushLimb / muscle crushWistarMaleAdministered for 2 weeks before contusion and continued after injury
Model: Standardised contusion injury of the gastrocnemius muscle
Proanthocyanidolic oligomers brought satellite cell activation forward to 4 h post-contusion, abolished the neutrophil rise, shifted the macrophage response earlier with resolution by day 5, raised IL-10 at day 3, and completed muscle fibre regeneration by day 14 whereas placebo animals had not.
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.68. Machine-extracted fields require source verification.