Molecular mechanisms underlying effects of neural stem cells against traumatic axonal injury.
RatTBIFluid percussionSprague-DawleyMaleIntracerebral graft
Model: Parasagittal fluid percussion traumatic brain injury with traumatic axonal injury, plus in vitro rapid stretch injury
Human neural stem cell grafts reduced traumatic axonal injury by blocking abnormal amyloid precursor protein accumulation and counteracted the injury-induced rise in neuronal alpha-smooth muscle actin, with GDNF offsetting stretch-induced neurite shortening and actin aggregation through calcineurin…
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