CX3CL1 is neuroprotective in permanent focal cerebral ischemia in rodents.
MixedIschaemia-reperfusionCerebral (MCAO/stroke)C57BL/6 wild type, cx3cl1 knockout, cx3cr1(GFP/GFP) and adenosine A1 receptor knockout miceMaleAcute administration at the time of permanent middle cerebral artery occlusion
Model: Permanent middle cerebral artery occlusion, with in vitro oxygen-glucose deprivation
Exogenous CX3CL1 reduced infarct size, neurological deficits and caspase-3 activation with effects lasting up to 50 days, dependent on adenosine A1 receptor signalling, yet cx3cl1 and cx3cr1 deficient mice sustained less injury and CX3CL1 increased damage in cx3cl1 knockout mice.
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