Aerosolized human extracellular superoxide dismutase prevents hyperoxia-induced lung injury.
MouseOtherCD-1FemaleAerosol inhalation10,000 units per dayDuring hyperoxic exposure
Model: Hyperoxia-induced lung injury with fraction of inspired oxygen greater than 95 per cent
Aerosolised rhEC-SOD raised day 3 survival to 95.8 per cent against 57.1 per cent in controls, 33.3 per cent with albumin and 75 per cent with copper-zinc superoxide dismutase, and reduced lung oedema and systemic oxidative stress.
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