CD11d Antibody Treatment Improves Recovery in Spinal Cord-Injured Mice.
MouseSpinal cord injuryCompressionC57BL/6FemaleIntravenous2, 24 and 48 h after injury
Model: 8 g clip compression injury at the fourth thoracic spinal segment
Anti-CD11d treatment reduced neutrophil infiltration, myeloperoxidase activity, reactive oxygen species, lipid peroxidation and scarring, increased white matter sparing and serotonin immunoreactivity caudal to the lesion, and improved locomotor recovery.
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