Inhibition of TLR2 promotes graft function in a murine model of renal transplant ischemia-reperfusion injury.
MouseIschaemia-reperfusionRenalC57BL/6IntravenousBefore reperfusion of the transplanted kidney
Model: Isograft renal transplantation with 30 min of cold ischaemia
OPN301 improved graft function, with blood urea nitrogen of 19.8 plus or minus 1.9 micromolar against 33.9 plus or minus 3.2 in isotype-treated mice, preserved tubular structure and reduced C3d deposition.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.72. Machine-extracted fields require source verification.