Fibronectin inhibits chronic pain development after spinal cord injury.
RatSpinal cord injuryCompressionSprague-DawleyMaleIntraspinal injection into the spinal dorsal column50 microgram/mL, 5 microlitre total volume delivered at 1 m…Immediately after spinal cord injury
Model: Spinal cord dorsal column crush
A single fibronectin injection prevented development of mechanical allodynia over 8 months but did not alter thermal hyperalgesia; the effect depended on the CS-1 motif and was accompanied by reduced inflammation and barrier permeability and preserved dorsal horn serotonin.
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.