Acid suppression increases rates of Barrett's esophagus and esophageal injury in the presence of duodenal reflux.
RatOtherSprague-DawleyMalen = 136 rats (control n=33, combined reflux n=34, PPI n=34, gas…Following oesophagoduodenostomy
Model: Oesophagoduodenostomy-induced duodenal reflux oesophageal injury, with or without gastrectomy
Acid suppression in the presence of duodenal refluxate increased the incidence of Barrett's mucosa (62 percent with PPI and 71 percent after gastrectomy versus 27 percent with combined reflux), increased erosions and proliferative marker expression, and suppressed acute but not chronic inflammation.
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