Synthesis and biological evaluation of novel dimethyl[1,1'-biphenyl]-2,2'-dicarboxylate derivatives containing thiazolidine-2,4-dione for the treatment of concanavalin A-induced acute liver injury of BALB/c mice.

Synthesis and biological evaluation of novel dimethyl[1,1'-biphenyl]-2,2'-dicarboxylate derivatives containing thiazolidine-2,4-dione for the treatment of concanavalin A-induced acute liver injury of BALB/c mice.

Model: Concanavalin A-induced immune-mediated acute liver injury; carrageenan-induced paw oedema

Compound 7k dose-dependently inhibited paw oedema and lowered serum ALT and AST in concanavalin A-induced hepatitis, with histopathology indicating better hepatoprotection than bifendate.

Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.