Administration of thimerosal to infant rats increases overflow of glutamate and aspartate in the prefrontal cortex: protective role of dehydroepiandrosterone sulfate.
RatChemical/toxinWistarMalen = Neonatal cohort N=28 (5 to 6 per group across five groups);…Intraperitoneal injection (neonatal model); intracerebral microdialysis perfusion (acute model)80 mg/kg intraperitoneally in the neonatal model; 100 micro…30 min before each thimerosal injection in the neonatal model; co-applied with…
Model: Thimerosal-induced excitotoxic amino acid imbalance in the prefrontal cortex, neonatal intramuscular exposure and acute intracerebral perfusion
DHEAS prevented the thimerosal-induced rise in extracellular glutamate and aspartate in both the neonatal and acute models, but by itself reduced glycine and alanine overflow and so added to the thimerosal effect on those inhibitory amino acids.
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