Effects of c-Jun N-terminal kinase signaling pathway on severe acute pancreatitis-associated lung injury.
RatChemical/toxinSprague-DawleyMalen = 72 rats in three groups (sham operation, severe acute pancr…
Model: Severe acute pancreatitis-associated lung injury induced by retrograde pancreatic duct injection of 5 percent sodium taurocholate
SP600125 reduced lung wet-to-dry weight ratio, myeloperoxidase activity, IL-1beta, TNF-alpha, ICAM-1 and phosphorylated JNK, and lowered lung injury scores relative to untreated severe acute pancreatitis.
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.