Minocycline improves functional outcomes, memory deficits, and histopathology after endovascular perforation-induced subarachnoid hemorrhage in rats.
RatHaemorrhage/shockUnspecifiedSprague-DawleyMalen = 118 ratsIntraperitoneal injection45 mg/kg or 135 mg/kg1 h after induction of subarachnoid haemorrhage
Model: Endovascular perforation-induced subarachnoid haemorrhage
High-dose minocycline reduced brain water content and MMP-9 activity at 24 h, improved spatial memory and attenuated hippocampal and cortical neuronal loss; low-dose minocycline did not reduce brain oedema.
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