Dopamine inhibits pulmonary edema through the VEGF-VEGFR2 axis in a murine model of acute lung injury.
MouseEndotoxin/LPSBALB/c, C57BL/6 and dopamine receptor D2 knockout miceMale50 mg/kg body weightPretreatment before lipopolysaccharide challenge
Model: Lipopolysaccharide-induced acute lung injury
Dopamine pretreatment reduced lipopolysaccharide-induced oedema and myeloperoxidase activity and increased survival from 0 to 75 percent, acting through the dopamine D2 receptor and the VEGF-VEGFR2 axis; a D2DR agonist failed to reduce oedema in D2DR knockout mice.
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