Toll-like receptor 5 agonist protects mice from dermatitis and oral mucositis caused by local radiation: implications for head-and-neck cancer radiotherapy.

Toll-like receptor 5 agonist protects mice from dermatitis and oral mucositis caused by local radiation: implications for head-and-neck cancer radiotherapy.

Model: Local single-dose (10, 15, 20 or 25 Gy) or fractionated (10 plus 15 Gy, or 3 times 10 Gy) irradiation of the head and neck area

CBLB502 reduced dermatitis and mucositis severity, accelerated tissue recovery and limited weight loss after single doses of 15 and 20 Gy but not 25 Gy, and after cumulative fractionated doses of 25 and 30 Gy, without protecting the syngeneic tumour and while inhibiting growth of TLR5-expressing tu…

Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.