Paranodal myelin damage after acute stretch in Guinea pig spinal cord.
Guinea pigSpinal cord injuryDistractionFemaleApplied after stretch injury, to test restoration of conduction
Model: Acute mechanical stretch injury of isolated guinea pig spinal cord (white matter), causing paranodal myelin disruption and axonal conduction failure
Anatomical evidence showed paranodal myelin disruption with exposure and redistribution of potassium channels and paranodal myelin decompaction after mechanical insult, arising from both the initial physical impact and secondary calcium-dependent biochemical reactions. 4-Aminopyridine partially res…
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.