Rebamipide promotes healing of colonic ulceration through enhanced epithelial restitution.
RatChemical/toxinWistarMaleIntrarectal (enema)Treatment started on day 7 after trinitrobenzene sulfonic acid administration,…
Model: Acute colitis with colonic ulceration induced by intrarectal trinitrobenzene sulfonic acid; complemented by in vitro wound healing (scratch) assays in rat intestinal epithelial cells
Intracolonic rebamipide accelerated healing of trinitrobenzene sulfonic acid induced ulcers and significantly inhibited the rise in colonic wet weight. In vitro it enhanced epithelial cell migration through extracellular signal-regulated kinase phosphorylation and Rho kinase activation.
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