Echinacea alkamides prevent lipopolysaccharide/D-galactosamine-induced acute hepatic injury through JNK pathway-mediated HO-1 expression.
MouseEndotoxin/LPSICRMale
Model: Acute fulminant hepatitis induced by lipopolysaccharide plus D-galactosamine; complemented by lipopolysaccharide-stimulated murine macrophages in vitro
Alkamides Alk-8/9 dose-dependently induced haem oxygenase-1 in lipopolysaccharide-stimulated macrophages via JNK signalling, and in lipopolysaccharide/D-galactosamine treated mice they markedly induced hepatic c-jun and haem oxygenase-1 while suppressing serum aminotransferase activities, tumour ne…
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