Neutralization of chemokine CXCL14 (BRAK) expression reduces CCl4 induced liver injury and steatosis in mice.
MouseChemical/toxinMale and female
Model: Carbon tetrachloride induced acute liver injury, steatosis and acute liver failure
Anti-CXCL14 antibody treatment reduced the severity of carbon tetrachloride induced liver injury, with significant reductions in hepatic necrosis area (p < 0.05), liver fat deposition (p < 0.01) and serum malondialdehyde (p < 0.05), and reduced mortality from carbon tetrachloride induced liver fail…
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