The effect of low-dose Continuous Erythropoietin receptor activator in an experimental model of acute Cyclosporine A induced renal injury.
RatChemical/toxinSprague-DawleyMalen = 12 rats, 6 per groupDescribed only as low dose; the numeric dose was not statedGiven during the 28-day period of cyclosporine A exposure
Model: Medium-dose cyclosporine A exposure for 28 days, producing acute renal tubulo-interstitial injury with macrophage sequestration and pancreatic islet cell damage
Cyclosporine A induced functional kidney damage that low-dose CERA did not improve. CERA showed a trend to osteopontin upregulation with increased renal macrophage infiltration and enhanced parenchymal transforming growth factor beta 1 and interleukin-10 relative to controls, and ameliorated pancre…
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