PRECLINICAL PUBLICATION · 2011

Antifibrotic effects of Smad4 small interfering RNAs in injured skeletal muscle after acute contusion.

Mouse / Other

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 21913159 ↗2011Reported benefit

MouseOtherC57BLFemaleIntramuscular injectionAfter contusion

Model: Acute skeletal muscle (gastrocnemius) contusion

Lentivirus-mediated Smad4 siRNA knocked down Smad4, reduced fibrosis and improved strength of contused skeletal muscle.

Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.