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PRECLINICAL PUBLICATION · 2011

Protein C concentrate controls leukocyte recruitment during inflammation and improves survival during endotoxemia after efficient in vivo activation.

Mouse / Endotoxin/LPS

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 21907691 ↗2011Reported benefit

Protein C concentrate controls leukocyte recruitment during inflammation and improves survival during endotoxemia after efficient in vivo activation.

MouseEndotoxin/LPSC57BLIntravenous100 U/kgDuring acute inflammation

Model: LPS endotoxemia and TNF-alpha/trauma-induced acute inflammation

Protein C concentrate inhibited leukocyte recruitment and improved survival during murine endotoxemia (75% vs 25%).

Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.