PebbleAtlas
PEBBLE / ATLAS
Open research access
PRECLINICAL PUBLICATION · 2011

Post-injury delivery of rAAV2-CNTF combined with short-term pharmacotherapy is neuroprotective and promotes extensive axonal regeneration after optic nerve trauma.

Rat / Other

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 21861632 ↗2011Reported benefit

Post-injury delivery of rAAV2-CNTF combined with short-term pharmacotherapy is neuroprotective and promotes extensive axonal regeneration after optic nerve trauma.

RatOtherWistarFemaleIntravitrealAt time of injury plus 3 and 10 days postoperatively

Model: Optic nerve transection with peripheral nerve graft

rAAV2-CNTF gene delivery combined with short-term CNTF and cAMP support increased retinal ganglion cell survival and axonal regeneration after optic nerve trauma.

Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.