Systemic delivery of BH4 anti-apoptotic peptide using CPPs prevents cardiac ischemia-reperfusion injuries in vivo.
MouseIschaemia-reperfusionCardiacC57BLIntravenous1 mg/kg5 min before reperfusion
Model: Myocardial ischaemia-reperfusion injury
A single low dose of CPP-BH4 peptide reduced infarct size by about 47% and apoptosis by about 60% after cardiac ischaemia-reperfusion.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.