PRECLINICAL PUBLICATION · 2011

Minocycline restores sAPPalpha levels and reduces the late histopathological consequences of traumatic brain injury in mice.

Mouse / TBI

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 21770756 ↗2011Reported benefit

MouseTBIWeight-drop / impact-accelerationMaleIntraperitoneal90 mg/kg then 45 mg/kg5 min, 3 h and 9 h post-TBI

Model: Weight-drop traumatic brain injury

Minocycline attenuated the post-TBI decrease in sAPPalpha and reduced long-term brain atrophy and gliosis.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.