PRECLINICAL PUBLICATION · 2011

High molecular weight hyaluronic acid limits astrocyte activation and scar formation after spinal cord injury.

Rat / Spinal cord injury

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

High molecular weight hyaluronic acid hydrogel (crosslinked)

PMID 21753237 ↗2011Reported benefit

High molecular weight hyaluronic acid limits astrocyte activation and scar formation after spinal cord injury.

RatSpinal cord injuryHemisection / partialSprague-DawleyIntraspinal implant at lesion siteAt time of injury

Model: Spinal dorsal hemisection injury

High molecular weight hyaluronic acid hydrogel implants reduced immune cell infiltration, CSPG deposition and astrocyte activation after spinal cord injury.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.