Mesenchymal stem cells stably transduced with a dominant-negative inhibitor of CCL2 greatly attenuate bleomycin-induced lung damage.

Mesenchymal stem cells stably transduced with a dominant-negative inhibitor of CCL2 greatly attenuate bleomycin-induced lung damage.

Model: Bleomycin-induced lung injury (ARDS model)

MSCs engineered to express the dominant-negative CCL2 inhibitor 7ND attenuated bleomycin-induced lung damage and improved survival in mice.

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