Tumor necrosis factor-alpha synthesis inhibitor, 3,6'-dithiothalidomide, reverses behavioral impairments induced by minimal traumatic brain injury in mice.
MouseTBIWeight-drop / impact-accelerationICRMale28 mg/kg (low) or 56 mg/kg (high)1 h before injury, or 1 or 12 h post-injury
Model: Closed head weight-drop mild/minimal traumatic brain injury
A single dose of the TNF-alpha synthesis inhibitor 3,6'-dithiothalidomide fully reversed cognitive impairments after mild traumatic brain injury in mice.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.