PRECLINICAL PUBLICATION · 2011

Increased local concentration of complement C5a contributes to incisional pain in mice.

Mouse / Wound

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 21736743 ↗2011Reported benefit

MouseWoundC57BL/6MaleLocal administration to wound areaAfter incision

Model: Hind paw incision (incisional/postoperative pain)

Local C5a receptor antagonism with PMX53 suppressed incision-induced mechanical allodynia and heat hyperalgesia in mice.

Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.