Drug repurposing for vascular protection after acute ischemic stroke.
RatIschaemia-reperfusionCerebral (MCAO/stroke)Wistar, spontaneously hypertensive (SHR), Goto-KakizakiMale
Model: Experimental ischaemic stroke (cerebral ischaemia/reperfusion)
Repurposed candesartan, minocycline and atorvastatin each reduced infarct size, improved neurological outcome and decreased haemorrhagic transformation after experimental stroke.
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