Controlled cortical impact traumatic brain injury in 3xTg-AD mice causes acute intra-axonal amyloid-beta accumulation and independently accelerates the development of tau abnormalities.

Controlled cortical impact traumatic brain injury in 3xTg-AD mice causes acute intra-axonal amyloid-beta accumulation and independently accelerates the development of tau abnormalities.

Model: Controlled cortical impact traumatic brain injury

Gamma-secretase inhibition with Compound E blocked post-traumatic amyloid-beta accumulation but did not affect tau pathology after controlled cortical impact in 3xTg-AD mice.

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