PebbleAtlas
PEBBLE / ATLAS
Open research access
← Studies/PMID 21704679
PRECLINICAL PUBLICATION · 2011

Vascular endothelial growth factor and platelet derived growth factor modulates the glial response to a cortical stab injury.

Rat / TBI

Read on PubMed ↗Suggest a correction

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 21704679 ↗2011Mixed findings

Vascular endothelial growth factor and platelet derived growth factor modulates the glial response to a cortical stab injury.

RatTBIPenetrating / ballisticSprague-DawleyMaleIntrastriatal injection20 pg (combination)At the same time as injury

Model: Cortical stab injury (striatal injection)

A single VEGF/PDGF bolus delayed the early glial response to cortical stab injury but evoked persistent astrogliosis and microglial activation up to 60 days.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.