Constitutive activation of epithelial TLR4 augments inflammatory responses to mucosal injury and drives colitis-associated tumorigenesis.
MouseChemical/toxinVillin-TLR4 transgenic
Model: DSS colitis and AOM-DSS colitis-associated tumorigenesis
A TLR4/MD-2 antagonist antibody inhibited colitis-associated neoplasia in mice, and constitutive epithelial TLR4 activation increased susceptibility to colitis and tumorigenesis.
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