Simvastatin in traumatic brain injury: effect on brain edema mechanisms.
RatTBIFluid percussionSprague-DawleyMaleOral37.5 mg/kg1 h and 6 h after TBI
Model: Lateral fluid percussion traumatic brain injury
Simvastatin reduced post-traumatic brain oedema, neurological deficits and blood-brain barrier permeability after fluid percussion TBI in rats by preserving tight junctions and limiting neutrophil infiltration.
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