Studies of locomotor network neuroprotection by the selective poly(ADP-ribose) polymerase-1 inhibitor PJ-34 against excitotoxic injury to the rat spinal cord in vitro.
RatSpinal cord injuryUnspecifiedWistarBath application (in vitro)60 microM
Model: In vitro kainate excitotoxic injury to spinal cord locomotor networks (models acute spinal injury)
The PARP-1 inhibitor PJ-34 preserved spinal cord histology after excitotoxic injury but restored fictive locomotion only when the excitotoxic insult was moderate.
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.