Post-injury administration of NAAG peptidase inhibitor prodrug, PGI-02776, in experimental TBI.
RatTBIFluid percussionSprague-DawleyMaleintraperitoneal10 mg/kg30 min after injury
Model: lateral fluid percussion TBI
Post-injury PGI-02776 (10 mg/kg) reduced hippocampal neuronal degeneration and improved cognitive performance after TBI.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.