The selective neuronal nitric oxide synthase inhibitor 7-nitroindazole has acute analgesic but not cumulative effects in a rat model of peripheral neuropathy.

The selective neuronal nitric oxide synthase inhibitor 7-nitroindazole has acute analgesic but not cumulative effects in a rat model of peripheral neuropathy.

Model: sciatic nerve cuff (peripheral neuropathy)

7-NI (20-30 mg/kg) had an acute analgesic effect but repeated early administration had no pre-emptive or cumulative effect on the neuropathy.

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