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← Studies/PMID 21510818
PRECLINICAL PUBLICATION · 2011

Inhibition of Ras-GTPase farnesylation and the ubiquitin-proteasome system or treatment with angiotensin-(1-7) attenuates spinal cord injury-induced cardiac dysfunction.

Rat / Spinal cord injury

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PMID 21510818 ↗2011Mixed findings

Inhibition of Ras-GTPase farnesylation and the ubiquitin-proteasome system or treatment with angiotensin-(1-7) attenuates spinal cord injury-induced cardiac dysfunction.

RatSpinal cord injuryContusionSprague-Dawleyex vivo perfusion before ischaemia6 or 12 months after SCI, acutely before cardiac ischaemia

Model: weight-drop contusive spinal cord injury (T13) with ex vivo cardiac ischaemia-reperfusion

FPTIII, MG132 or angiotensin-(1-7) improved cardiac recovery after ischaemia in SCI-6 but not SCI-12 animals.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.