PRECLINICAL PUBLICATION · 2011

Delayed intrathecal delivery of RhoA siRNA to the contused spinal cord inhibits allodynia, preserves white matter, and increases serotonergic fiber growth.

Rat / Spinal cord injury

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 21443453 ↗2011Mixed findings

RatSpinal cord injuryContusionSprague-DawleyFemaleintrathecal (lumbar puncture) and intraspinal injection1 day after injury (delayed)

Model: contusion spinal cord injury (T9-T10)

RhoA siRNA decreased allodynia and preserved white matter and serotonergic fibres but did not significantly improve locomotion.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.