PRECLINICAL PUBLICATION · 2011

Simvastatin regulates CXC chemokine formation in streptococcal M1 protein-induced neutrophil infiltration in the lung.

Mouse / Other

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 21441352 ↗2011Reported benefit

MouseOtherC57BL/6Malepretreatment before M1 protein challenge

Model: streptococcal M1 protein-induced acute lung injury

Simvastatin reduced M1 protein-induced neutrophil infiltration and oedema by decreasing pulmonary CXC chemokine formation.

Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.