Limb ischemic preconditioning mitigates lung injury induced by haemorrhagic shock/resuscitation in rats.
RatHaemorrhage/shockControlledSprague-DawleyMalen = 12 rats per grouplimb tourniquet3 cycles of 10 min ischaemia/10 min reperfusionimmediately before haemorrhagic shock (preconditioning)
Model: haemorrhagic shock (MAP 40-45 mmHg, 120 min) and resuscitation
Limb ischaemic preconditioning mitigated haemorrhagic shock/resuscitation lung injury via an HO-1-dependent mechanism.
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