A selective phosphodiesterase-4 inhibitor reduces leukocyte infiltration, oxidative processes, and tissue damage after spinal cord injury.
RatSpinal cord injuryCompressionWistarintravenous0.5, 1.0 and 3.0 mg/kg2-60 h post-injury
Model: clip-compression thoracic spinal cord injury (moderately severe)
The PDE4 inhibitor (0.5-1.0 mg/kg) reduced oxidative stress and leukocyte infiltration and improved locomotion and neuropathic pain after SCI.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.