Pretreatment by low-dose fibrates protects against acute free fatty acid-induced renal tubule toxicity by counteracting PPARalpha deterioration.
MouseChemical/toxinFemaleOral (in diet)0.1% clofibrate dietPretreatment (before injury)
Model: Free fatty acid-overload nephropathy (acute tubular injury)
Low-dose clofibrate pretreatment prevented acute tubular injury without metabolite accumulation via PPARalpha-dependent effects, though PPARalpha-independent toxicity persisted in null mice.
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.