PRECLINICAL PUBLICATION · 2011

Bone marrow-derived mesenchymal stem cells transduced with scleraxis improve rotator cuff healing in a rat model.

Rat / Other

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Bone marrow-derived MSCs transduced with adenoviral scleraxis (Ad-Scx)

PMID 21335341 ↗2011Reported benefit

Bone marrow-derived mesenchymal stem cells transduced with scleraxis improve rotator cuff healing in a rat model.

RatOtherLewisn = 60Local implantation in fibrin glue carrierAt time of repair

Model: Unilateral supraspinatus tendon detachment and repair (rotator cuff)

Scleraxis-transduced MSCs increased fibrocartilage and improved biomechanical strength of the healing tendon-bone interface versus MSCs alone at early time points.

Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.