Acute effects of a selective cannabinoid-2 receptor agonist on neuroinflammation in a model of traumatic brain injury.
MouseTBIControlled cortical impactC57BL/6Malen = 301 h and 24 h after injury
Model: Controlled cortical contusion impact injury (CCI)
The CB2R agonist 0-1966 reduced cerebral edema, substance P and macrophage/microglial activation and improved acute motor and exploratory performance after TBI.
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