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← Studies/PMID 21302134
PRECLINICAL PUBLICATION · 2012

Sphingosine-1-phosphate attenuates lung injury induced by intestinal ischemia/reperfusion in mice: role of inducible nitric-oxide synthase.

Mouse / Ischaemia-reperfusion

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Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 21302134 ↗2012Reported benefit

Sphingosine-1-phosphate attenuates lung injury induced by intestinal ischemia/reperfusion in mice: role of inducible nitric-oxide synthase.

MouseIschaemia-reperfusionIntestinal / mesentericC57BL/6MaleIntraperitoneal injection100 micrograms/kgAt reperfusion

Model: Intestinal ischemia/reperfusion (superior mesenteric artery occlusion 45 min then 6 h reperfusion) inducing acute lung injury

S1P attenuated intestinal I/R-induced lung injury, reducing oedema, oxidative stress, inflammation and iNOS-mediated NO generation.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.