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PRECLINICAL PUBLICATION · 2011

Reduction in antioxidant enzyme expression and sustained inflammation enhance tissue damage in the subacute phase of spinal cord contusive injury.

Rat / Spinal cord injury

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 21299884 ↗2011Reported benefit

Reduction in antioxidant enzyme expression and sustained inflammation enhance tissue damage in the subacute phase of spinal cord contusive injury.

RatSpinal cord injuryContusionSprague-DawleyFemaleIntraspinal (gene transfer); delayed administration (chABC)SOD right after injury; chABC at day 3 post injury

Model: Severe contusive spinal cord injury at thoracic segment 10

Antioxidant enzyme gene transfer attenuated cell apoptosis and delayed chondroitinase ABC improved hindlimb locomotion after severe SCI.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.