PRECLINICAL PUBLICATION · 2011

Expression and detrimental role of hematopoietic prostaglandin D synthase in spinal cord contusion injury.

Mouse / Spinal cord injury

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

HQL-79 (HPGDS selective inhibitor)

PMID 21294159 ↗2011Reported benefit

Expression and detrimental role of hematopoietic prostaglandin D synthase in spinal cord contusion injury.

MouseSpinal cord injuryContusionHPGDS knockout and wild-typeFemaleSystemic

Model: Spinal cord contusion injury

HPGDS deficiency or the inhibitor HQL-79 reduced secondary tissue damage and improved locomotor recovery after spinal cord contusion, indicating a detrimental role of PGD2.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.