Evaluation of milnacipran, in comparison with amitriptyline, on cold and mechanical allodynia in a rat model of neuropathic pain.
RatOtherIntraperitonealMinimum effective dose 2.5 mg/kg (cold), 10 mg/kg (mechanic…After established neuropathy
Model: Chronic constriction injury of the sciatic nerve
Milnacipran reduced both cold and mechanical allodynia and was as efficacious as amitriptyline in nerve constriction-induced neuropathic pain.
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